U.S. regulators have approved an experimental treatment from Johnson & Johnson that may offer hope to multiple myeloma patients who have run out of other options against the blood cancer.
The U.S. Food and Drug Administration on Monday said it had approved Darzalex (daratumumab) for patients who had already undergone at least three prior standard treatments for the cancer, which affects infection-fighting plasma cells that reside in the bone marrow.
Darzalex, given as an infusion, is a monoclonal antibody that works by helping the immune system attack cancer cells. J&J licensed worldwide rights to the medicine from Danish biotech company Genmab A/S.
In one 106-patient study, tumors shrank or were no longer detectable in 29 percent of patients taking Darzalex, and the benefit lasted for an average of 7.4 months. In a second trial, involving 42 patients, 36 percent of patients taking the J&J/Genmab drug saw a partial or complete reduction in tumors.
Researchers said it is the first antibody drug to demonstrate effectiveness against myeloma without having to be combined with other medicines.
JUMP
Tuesday, November 17, 2015
Friday, November 6, 2015
Pesticide Peddler Monsanto Wins 2015 Rubber Dodo Award
TUCSON, Ariz.— Monsanto, producer and seller of Roundup and its toxic active ingredient glyphosate, is the recipient of the Center for Biological Diversity’s 2015 Rubber Dodo Award, given annually to those who have done the most to destroy wild places, species and biological diversity. Glyphosate is now used in more than 160 countries, and more than 1.4 billion pounds are applied each year. It has been classified as a “probable human carcinogen” by the World Health Organization and its heavy use, particularly on herbicide-resistant GMO crops, also developed by Monsanto, is considered a leading cause of the recent, drastic 80 percent decline in monarch butterflies.
Previous Rubber Dodo winners include U.S. Department of Agriculture’s Wildlife Services (2014), the Koch brothers (2013), climate denier James Inhofe (2012), the U.S. Chamber of Commerce (2011), former BP CEO Tony Hayward (2010), massive land speculator Michael Winer (2009), Alaska Gov. Sarah Palin (2008) and Interior Secretary Dirk Kempthorne (2007).
“The science is increasingly clear that glyphosate is damaging wildlife and putting people at serious risk, yet Monsanto continues to aggressively peddle the stuff to farmers and really any customer it can find,” said Kierán Suckling, the Center’s executive director. “It’s hard to fathom the depth of the damage that glyphosate is doing, but its toxic legacy will live on for generations, whether it’s through threatening monarchs with extinction or a heightened risk of cancer for people where it’s spread.”
Earlier this week the Center released an analysis that found more than half of the glyphosate sprayed in California is applied in the state’s eight most impoverished counties, where the populations are predominantly Hispanic or Latino.
“Those sitting in Monsanto’s boardrooms and corporate offices won’t pay the price for this dangerous pesticide. It’s going to be people on the ground where it’s sprayed,” Suckling said. “This kind of callous pursuit of profits is at the core of what’s driving the loss of wildlife and diversity on a massive scale around the globe.”
More than 15,000 people cast their votes in this year’s Rubber Dodo contest. Other official nominees were Volkswagen, Sen. John McCain (R-Ariz.), Exxon and notorious Nevada rancher Cliven Bundy.
Background on the Dodo
In 1598 Dutch sailors landing on the Indian Ocean island of Mauritius discovered a flightless, 3-foot-tall, extraordinarily friendly bird. Its original scientific name was Didus ineptus. (Contemporary scientists use the less defamatory Raphus cucullatus.) To the rest of the world, it’s the dodo — possibly the most famous extinct species on Earth after the dinosaurs. It evolved over millions of years with no natural predators and eventually lost the ability to fly, becoming a land-based consumer of fruits, nuts and berries. Having never known predators, it showed no fear of humans or the menagerie of animals accompanying them to Mauritius.
Its trusting nature led to its rapid extinction. By 1681 the dodo had vanished, hunted and outcompeted by humans, dogs, cats, rats, macaques and pigs. Humans logged its forest cover while pigs uprooted and ate much of the understory vegetation.
The origin of the name dodo is unclear. It likely came from the Dutch word dodoor, meaning “sluggard,” the Portuguese word doudo, meaning “fool” or “crazy,” or the Dutch word dodaars meaning “plump-arse” (that nation’s name for the little grebe).
The dodo’s reputation as a foolish, ungainly bird derives in part from its friendly naiveté and the very plump captives that were taken on tour across Europe. The animal’s reputation was cemented with the 1865 publication of Lewis Carroll’s Alice's Adventures in Wonderland.
Based on skeleton reconstructions and the discovery of early drawings, scientists now believe that the dodo was a much sleeker animal than commonly portrayed. The rotund European exhibitions were likely produced by overfeeding captive birds.
The Center for Biological Diversity is a national, nonprofit conservation organization with more than 900,000 members and online activists dedicated to the protection of endangered species and wild places.
Previous Rubber Dodo winners include U.S. Department of Agriculture’s Wildlife Services (2014), the Koch brothers (2013), climate denier James Inhofe (2012), the U.S. Chamber of Commerce (2011), former BP CEO Tony Hayward (2010), massive land speculator Michael Winer (2009), Alaska Gov. Sarah Palin (2008) and Interior Secretary Dirk Kempthorne (2007).
“The science is increasingly clear that glyphosate is damaging wildlife and putting people at serious risk, yet Monsanto continues to aggressively peddle the stuff to farmers and really any customer it can find,” said Kierán Suckling, the Center’s executive director. “It’s hard to fathom the depth of the damage that glyphosate is doing, but its toxic legacy will live on for generations, whether it’s through threatening monarchs with extinction or a heightened risk of cancer for people where it’s spread.”
Earlier this week the Center released an analysis that found more than half of the glyphosate sprayed in California is applied in the state’s eight most impoverished counties, where the populations are predominantly Hispanic or Latino.
“Those sitting in Monsanto’s boardrooms and corporate offices won’t pay the price for this dangerous pesticide. It’s going to be people on the ground where it’s sprayed,” Suckling said. “This kind of callous pursuit of profits is at the core of what’s driving the loss of wildlife and diversity on a massive scale around the globe.”
More than 15,000 people cast their votes in this year’s Rubber Dodo contest. Other official nominees were Volkswagen, Sen. John McCain (R-Ariz.), Exxon and notorious Nevada rancher Cliven Bundy.
Background on the Dodo
In 1598 Dutch sailors landing on the Indian Ocean island of Mauritius discovered a flightless, 3-foot-tall, extraordinarily friendly bird. Its original scientific name was Didus ineptus. (Contemporary scientists use the less defamatory Raphus cucullatus.) To the rest of the world, it’s the dodo — possibly the most famous extinct species on Earth after the dinosaurs. It evolved over millions of years with no natural predators and eventually lost the ability to fly, becoming a land-based consumer of fruits, nuts and berries. Having never known predators, it showed no fear of humans or the menagerie of animals accompanying them to Mauritius.
Its trusting nature led to its rapid extinction. By 1681 the dodo had vanished, hunted and outcompeted by humans, dogs, cats, rats, macaques and pigs. Humans logged its forest cover while pigs uprooted and ate much of the understory vegetation.
The origin of the name dodo is unclear. It likely came from the Dutch word dodoor, meaning “sluggard,” the Portuguese word doudo, meaning “fool” or “crazy,” or the Dutch word dodaars meaning “plump-arse” (that nation’s name for the little grebe).
The dodo’s reputation as a foolish, ungainly bird derives in part from its friendly naiveté and the very plump captives that were taken on tour across Europe. The animal’s reputation was cemented with the 1865 publication of Lewis Carroll’s Alice's Adventures in Wonderland.
Based on skeleton reconstructions and the discovery of early drawings, scientists now believe that the dodo was a much sleeker animal than commonly portrayed. The rotund European exhibitions were likely produced by overfeeding captive birds.
The Center for Biological Diversity is a national, nonprofit conservation organization with more than 900,000 members and online activists dedicated to the protection of endangered species and wild places.
Thursday, October 29, 2015
The Hildebrand Family circa 1936
Just posting this for myself.... I don't want to lose this.
Gals left to right:
Lenore, Helen, Rosalee, MOM, Anne, Mary
Uncle Bill, Grandma and Grandpa.
Lenore, Helen, Rosalee, MOM, Anne, Mary
Uncle Bill, Grandma and Grandpa.
 |
| Aunt Mary |
Our Annual October Get Together
We normally have our clambake this time of year. Unfortunately, my clam supplier closed up shop.
Instead, we had a BBQ. We had chicken, pasta salad, smoked sausage....Wendy brought over a crock pot full of shredded bbq pork and little buns for sliders.
Our dear friend, Chris, passed away in April. Things just aren't the same without him. But, he did make his presence known appearing as a beautiful rainbow!
The boys shot pool for hours. Wendy and Bubbie spent the night. Wendy and I had a Mimosa Party when we got up on Wed. Bubbie fished for a few hours.
BIG FUN!
Instead, we had a BBQ. We had chicken, pasta salad, smoked sausage....Wendy brought over a crock pot full of shredded bbq pork and little buns for sliders.
Our dear friend, Chris, passed away in April. Things just aren't the same without him. But, he did make his presence known appearing as a beautiful rainbow!
The boys shot pool for hours. Wendy and Bubbie spent the night. Wendy and I had a Mimosa Party when we got up on Wed. Bubbie fished for a few hours.
BIG FUN!
Sunday, October 18, 2015
Inching Toward a Cure for Multiple Myeloma
With new treatments transforming multiple myeloma into a chronic condition and additional therapies on the horizon, some experts believe a cure is within view.
Dana Davis, a 56-year-old school administrator in suburban Atlanta, remembers the rib pain first.
“I had an excuse for everything,” Davis says with a laugh. “But finally, my wife said I couldn’t ignore it any longer. She insisted that I go to the doctor. Pretty quickly, they found that I had anemia. Then they diagnosed multiple myeloma.”
That was 15 years ago. Davis has already survived three times longer than patients with even the best prognosis could have expected in the 20th century. The father of a son and two daughters when he was diagnosed, he has been able to watch those children grow up, take in a foster son, who is now 11, and see his first grandchild born.
And Davis is now part of a clinical trial of a targeted monoclonal antibody, daratumumab, that researchers hope will be a game changer in the treatment of myeloma. Even more amazing, Davis’ story is becoming more and more common.
A multiple myeloma diagnosis used to mean that a patient could only expect to survive three to five years — with only chemotherapy agents available for treatment. Today, that landscape has changed so much that it’s almost unrecognizable, with average survival nearly tripled and additional advances on the horizon with a sophisticated array of therapeutic options.
Doctors are trying established drugs in new combinations, doses and formulations that seem to cut down on the side effects of treatment, and also to lengthen stretches of progression-free survival (PFS). Some drugs in the clinical trial pipeline enlist the body’s own immune system to fight the disease, while others target cells with specific genetic mutations, or never-before-targeted systems that control cell processes. The fact that oral drugs are in development means that patients don’t have to travel to an infusion center every few weeks to keep their cancer under control.
Multiple myeloma remains an incurable disease, but it is becoming more manageable. Doctors are beginning to talk of it as a “chronic disease.” Some are optimistic enough to even say that a cure may be possible.
“It’s a massive convergence of our understanding of biology, the technology becoming available to understand myeloma cells and how they respond, the genetic subtypes of myeloma, the ability to engage both the patient community and researcher, to transfer data and information,” says Walter Capone, president and CEO of the Multiple Myeloma Research Foundation. “It’s truly a renaissance in our ability to make treatment of myeloma more precise and accelerate breakthroughs for patients.”
Approximately 22,000 Americans receive a multiple myeloma diagnosis each year. Myeloma is the second most common blood cancer, after lymphoma. It tends to strike African-Americans more often, and those older than 65.
Myeloma starts in the plasma cells of the bone marrow, white blood cells that, when healthy, are specialized immune cells, specifically B-cell lymphocytes that make antibodies. As the myeloma kindles, the plasma cells stop doing what they’re supposed to do and start making large amounts of an abnormal, non-functional antibody called “M protein.” These proteins and cells can clump together, forming hole-like cysts in the bone. If more than one cyst has formed, the diagnosis is “multiple” myeloma. M proteins and other substances made by myeloma cells also can etch away bone tissue, causing pain and breaks. They may thicken the blood, interfering with the normal function of kidneys, bone marrow, nerves and the immune system. And they can lead to high levels of blood calcium, causing dehydration and kidney problems or failure, or make patients susceptible to infection.
Myeloma is expensive. The incidence of lung cancer is 11 times greater than the incidence of multiple myeloma, but the annual costs associated with multiple myeloma are $100-plus million more than the costs associated with patients with lung cancer that has spread to the bones. The costs of the new drugs for a single patient range from $98,000 to $276,000 per year.
From Standard Treatment to New Territory
In recent years, the standard treatment has been a course of traditional, high-dose chemotherapy drugs like melphalan or cyclophosphamide, considered an “induction” phase of treatment meant to induce remission of the cancer prior to a stem cell transplant. Next, the patient receives a stem cell transplant. This grueling, months-long procedure replaces the diseased bone marrow with healthy marrow from a donor. The side effects of myeloma treatment can be harrowing: drops in blood counts, crushing fatigue, diarrhea, severe bone pain, relentless infections, nausea, heart damage.
Much More HERE
Dana Davis, a 56-year-old school administrator in suburban Atlanta, remembers the rib pain first.
“I had an excuse for everything,” Davis says with a laugh. “But finally, my wife said I couldn’t ignore it any longer. She insisted that I go to the doctor. Pretty quickly, they found that I had anemia. Then they diagnosed multiple myeloma.”
That was 15 years ago. Davis has already survived three times longer than patients with even the best prognosis could have expected in the 20th century. The father of a son and two daughters when he was diagnosed, he has been able to watch those children grow up, take in a foster son, who is now 11, and see his first grandchild born.
And Davis is now part of a clinical trial of a targeted monoclonal antibody, daratumumab, that researchers hope will be a game changer in the treatment of myeloma. Even more amazing, Davis’ story is becoming more and more common.
A multiple myeloma diagnosis used to mean that a patient could only expect to survive three to five years — with only chemotherapy agents available for treatment. Today, that landscape has changed so much that it’s almost unrecognizable, with average survival nearly tripled and additional advances on the horizon with a sophisticated array of therapeutic options.
Doctors are trying established drugs in new combinations, doses and formulations that seem to cut down on the side effects of treatment, and also to lengthen stretches of progression-free survival (PFS). Some drugs in the clinical trial pipeline enlist the body’s own immune system to fight the disease, while others target cells with specific genetic mutations, or never-before-targeted systems that control cell processes. The fact that oral drugs are in development means that patients don’t have to travel to an infusion center every few weeks to keep their cancer under control.
Multiple myeloma remains an incurable disease, but it is becoming more manageable. Doctors are beginning to talk of it as a “chronic disease.” Some are optimistic enough to even say that a cure may be possible.
“It’s a massive convergence of our understanding of biology, the technology becoming available to understand myeloma cells and how they respond, the genetic subtypes of myeloma, the ability to engage both the patient community and researcher, to transfer data and information,” says Walter Capone, president and CEO of the Multiple Myeloma Research Foundation. “It’s truly a renaissance in our ability to make treatment of myeloma more precise and accelerate breakthroughs for patients.”
Approximately 22,000 Americans receive a multiple myeloma diagnosis each year. Myeloma is the second most common blood cancer, after lymphoma. It tends to strike African-Americans more often, and those older than 65.
Myeloma starts in the plasma cells of the bone marrow, white blood cells that, when healthy, are specialized immune cells, specifically B-cell lymphocytes that make antibodies. As the myeloma kindles, the plasma cells stop doing what they’re supposed to do and start making large amounts of an abnormal, non-functional antibody called “M protein.” These proteins and cells can clump together, forming hole-like cysts in the bone. If more than one cyst has formed, the diagnosis is “multiple” myeloma. M proteins and other substances made by myeloma cells also can etch away bone tissue, causing pain and breaks. They may thicken the blood, interfering with the normal function of kidneys, bone marrow, nerves and the immune system. And they can lead to high levels of blood calcium, causing dehydration and kidney problems or failure, or make patients susceptible to infection.
Myeloma is expensive. The incidence of lung cancer is 11 times greater than the incidence of multiple myeloma, but the annual costs associated with multiple myeloma are $100-plus million more than the costs associated with patients with lung cancer that has spread to the bones. The costs of the new drugs for a single patient range from $98,000 to $276,000 per year.
From Standard Treatment to New Territory
In recent years, the standard treatment has been a course of traditional, high-dose chemotherapy drugs like melphalan or cyclophosphamide, considered an “induction” phase of treatment meant to induce remission of the cancer prior to a stem cell transplant. Next, the patient receives a stem cell transplant. This grueling, months-long procedure replaces the diseased bone marrow with healthy marrow from a donor. The side effects of myeloma treatment can be harrowing: drops in blood counts, crushing fatigue, diarrhea, severe bone pain, relentless infections, nausea, heart damage.
Much More HERE
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