Low dose whole body CT is nearly four times better than radiographic skeletal survey, the standard of care in the U.S., for determining the extent of disease in patients with multiple myeloma, a new study shows.
The study, conducted at the University of Maryland in Baltimore, included 51 patients who had both a radiographic skeletal survey as well as a low dose whole body CT examination. The total number of lesions detected in these patients with low dose whole body CT was 968 versus 248 detected by radiographic skeletal survey, said Kelechi Princewill, MD, the lead author of the study. "The stage of disease determines treatment, and the study found that in 31 patients, the stage of disease would have been different with low dose whole body CT. Thirteen patients would have been upstaged from stage I to stage II; nine patients would have been upstaged from stage I to stage III and nine patients would have been upstaged from stage II to III based on additional lesions detected on the low dose whole body CT," said Dr. Princewill.
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